Ultraviolet (UV) light induces the formation of bulky UV photoproducts in the genome that interfere with DNA replication and transcription. It is well-established how human cells repair UV light-induc

NIAID Data Ecosystem20

Discovery of Isaindigotone Derivatives as Novel Bloom’s Syndrome Protein (BLM) Helicase Inhibitors That Disrupt the BLM/DNA Interactions and Regulate the Homologous Recombination Repair

DNA损伤修复

抗癌药物设计

Homologous recombination repair (HRR), a crucial approach in DNA damage repair, is an attractive target in cancer therapy and drug design. The Bloom syndrome protein (BLM) is a 3′–5′ DNA helicase that

NIAID Data Ecosystem40

Structure of Escherichia coli HrpA in complex with ADP and dinucleotide dCdC

蛋白质-核酸复合物结构

RNA解旋酶机制

Structure of Escherichia coli HrpA in complex with ADP and dinucleotide dCdC Descriptor: ADENOSINE-5'-DIPHOSPHATE, ATP-dependent RNA helicase HrpA, DNA (5'-D(P*CP*C)-3'), ... Authors: Xin, B.G, Yuan,

Protein Data Bank Japan2024-05-15 更新30

Binary structure of DNA polymerase eta in complex with templating hypoxanthine

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