Cryo-EM structure of mouse agonist ML-SA1-bound TRPML1 channel at 2.32 Angstrom resolution

Cryo-EM structure of mouse agonist ML-SA1-bound TRPML1 channel at 2.32 Angstrom resolution Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-{2-oxo-2-[(4S)-2,2,4-trimethyl-3,4-dihydroquinolin-1(2H)-yl]ethyl}-1H-isoindole-1,3(2H)-dione, Mucolipin-1, ... Authors: Gan, N, Han, Y, Jiang, Y. Deposit date: 2021-11-04 Release date: 2022-02-02 Last modified: 2024-10-30 Method: ELECTRON MICROSCOPY (2.32 Å) Cite: Structural mechanism of allosteric activation of TRPML1 by PI(3,5)P 2 and rapamycin. Proc.Natl.Acad.Sci.USA, 119, 2022分辨率为2.32埃的小鼠源激动剂ML-SA1结合TRPML1通道的冷冻电镜（Cryo-EM）结构。结构表征组分：2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-{2-氧代-2-[(4S)-2,2,4-三甲基-3,4-二氢喹啉-1(2H)-基]乙基}-1H-异吲哚-1,3(2H)-二酮、粘脂素-1（Mucolipin-1），……。作者：Gan N、Han Y、Jiang Y。存档日期：2021-11-04。发布日期：2022-02-02。末次修改日期：2024-10-30。实验方法：电子显微镜（2.32 Å）。引用文献：《PI(3,5)P₂与雷帕霉素变构激活TRPML1的结构机制》，《美国国家科学院院刊》（Proc. Natl. Acad. Sci. USA），第119卷，2022年