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Dose-response modeling of early molecular and cellular key events in CAR-mediated hepatocarcinogenesis pathway. Mus musculus

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下载链接:
https://www.ncbi.nlm.nih.gov/bioproject/PRJNA237112
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Male and female CD-1 mice were administered dietary Phenobarbital for 2 or 7 days. In-life, enzyme activity, cell proliferation, genomic analysis, and Bench-mark dose modeling was carried out. The goal was to exmaine low-dose PB effects on early key events in CAR-mediated hepatocarcinogenesis. Overall design: PB at 0, 0.15, 1.5, 15, 75, or 150 mg/kg-day for 2 or 7 days to characterize multiple apical and molecular endpoints.
创建时间:
2014-01-31
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