SRC kinase bound to covalent inhibitor

SRC kinase bound to covalent inhibitor Descriptor: N-{2-[(5-chloro-2-{[4-(4-methylpiperazin-1-yl)phenyl]amino}pyrimidin-4-yl)amino]phenyl}propanamide, Proto-oncogene tyrosine-protein kinase Src Authors: Gurbani, D, Westover, K.D. Deposit date: 2017-08-28 Release date: 2019-02-27 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.402 Å) Cite: Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome. Cell Chem Biol, 26, 2019

与共价抑制剂结合的SRC激酶（SRC kinase）。描述符：N-{2-[(5-氯-2-{[4-(4-甲基哌嗪-1-基)苯基]氨基}嘧啶-4-基)氨基]苯基}丙酰胺，原癌基因酪氨酸蛋白激酶SRC（Proto-oncogene tyrosine-protein kinase Src）。作者：Gurbani D、Westover KD。提交日期：2017-08-28。发布日期：2019-02-27。最后修改日期：2024-11-20。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.402埃）。引用文献：《利用化合物混杂性识别激酶组内可靶向半胱氨酸》(Leveraging Compound Promiscuity to Identify Targetable Cysteines within the Kinome)，《细胞化学与生物学》(Cell Chem Biol)，第26卷，2019年。