X-ray Structure of c-Met kinase in complex with inhibitor 6-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl) quinoline.

Protein Data Bank Japan2023-12-20 更新2026-03-21 收录

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X-ray Structure of c-Met kinase in complex with inhibitor 6-((6-(4- fluorophenyl)-(1,2,4)triazolo(4,3-b)(1,2,4)triazin-3-yl)methyl) quinoline. Descriptor: 6-[[6-(4-fluorophenyl)-[1,2,4]triazolo[4,3-b][1,2,4]triazin-3-yl]methyl]quinoline, HEPATOCYTE GROWTH FACTOR RECEPTOR Authors: McTigue, M, Wickersham, J, Ryan, K. Deposit date: 2012-11-13 Release date: 2013-11-27 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.2 Å) Cite: Lessons from (S)-6-(1-(6-(1-Methyl-1H-Pyrazol-4-Yl)-[1,2, 4]Triazolo[4,3-B]Pyridazin-3-Yl)Ethyl)Quinoline (Pf-04254644), an Inhibitor of Receptor Tyrosine Kinase C-met with High Protein Kinase Selectivity But Broad Phosphodiesterase Family Inhibition Leading to Myocardial Degeneration in Rats. J.Med.Chem., 56, 2013

与抑制剂6-[[6-(4-氟苯基)-[1,2,4]三唑并[4,3-b][1,2,4]三嗪-3-基]甲基]喹啉结合的c-Met激酶X射线晶体结构。描述符：6-[[6-(4-氟苯基)-[1,2,4]三唑并[4,3-b][1,2,4]三嗪-3-基]甲基]喹啉、肝细胞生长因子受体（HEPATOCYTE GROWTH FACTOR RECEPTOR）。作者：McTigue, M、Wickersham, J、Ryan, K。存档日期：2012-11-13；发布日期：2013-11-27；最后修改日期：2023-12-20。实验方法：X射线衍射法（分辨率2.2 Å）。引用文献：《(S)-6-(1-(6-(1-甲基-1H-吡唑-4-基)-[1,2,4]三唑并[4,3-b]哒嗪-3-基)乙基)喹啉（Pf-04254644）的研究启示：一种对受体酪氨酸激酶c-Met具有高蛋白激酶选择性、可广泛抑制磷酸二酯酶家族并在大鼠中诱导心肌变性的受体酪氨酸激酶抑制剂》，《J.Med.Chem.》，56卷，2013年

创建时间：

2012-11-13