Breast cancer derived Evs cause liver fibrosis. [I]

breast cancer derived Evs carried NT5C2 to liver tissue, which causes inosine accumulation in liver. High inosine level suppressed ADAR1-P150 protein level and decreased global A-I editing level. Fibronectin-1 displayed a higher mRNA level due to the reduction of splicing sites' editing. Overall, breast cancer derived EVs cause liver fibrosis. mice recived inosine intraperitoneal injection and control.