Transcriptomic analysis of brain hypometabolism links the cholinergic and gingipain hypotheses of Alzheimer’s disease pathogenesis

Supplement data and figures from "Transcriptomic analysis of brain hypometabolism links the cholinergic and gingipain hypotheses of Alzheimer’s disease pathogenesis"<br>Preprint:https://www.biorxiv.org/content/10.1101/2019.12.23.887364v2<br><br>Github:https://github.com/leonfrench/AD-Allen-FDG<br><br>Supplement Figure 1: Differential expression of ER translocation genes in microglia from individuals with Alzheimer’s disease. In the top row, ROC curves show the proportion of ER translocation genes (y-axis, true positive fraction) across the genes tested for differential expression in microglia. The tested genes were ranked from the most overexpressed in early-pathology compared to no-pathology (A) and overexpressed in late-pathology compared to early-pathology (B). Subpanels C and D show the corresponding distributions with a black lines marking ER translocation genes across the differential expression rankings.