不同发育阶段斑马鱼视顶盖胶质细胞在生理和TBI条件下的转录组图谱数据集

本数据集包含早期幼年阶段(11 dpf), 晚期幼年阶段(17 dpf), 青年阶段(48 dpf), 和成年阶段(3 mpf)共四个胚后发育阶段生理(ctrl)和创伤性脑损伤(TBI, 3 dpi)条件下对斑马鱼视顶盖中三大胶质细胞类型富集后进行单细胞转录组测序的原始测序数据。此外，本数据集还包含成年视顶盖损伤后一个月(4 mpf-1 mpi)和二次损伤后(1 mpi-3 dpi)对三大胶质细胞富集后单细胞转录组测序的原始测序数据。最后，本数据集还包含在以上测序数据中筛选出来的每种胶质细胞在生理和TBI条件下单细胞测序结果分析的RData。

This dataset encompasses raw single-cell RNA sequencing (scRNA-seq) data of three major glial cell types enriched from the zebrafish optic tectum under both physiological (ctrl) and traumatic brain injury (TBI, 3 dpi) conditions, across four post-embryonic developmental stages: early juvenile (11 dpf), late juvenile (17 dpf), young adult (48 dpf), and adult (3 mpf). Furthermore, this dataset also contains raw scRNA-seq data of three major glial cell types enriched from the adult zebrafish optic tectum at one month post-injury (4 mpf-1 mpi) and following secondary injury (1 mpi-3 dpi). Lastly, this dataset includes RData files for the single-cell sequencing analysis of each glial cell type under physiological and TBI conditions, which were screened from the aforementioned sequencing data.

搜集汇总

背景与挑战

背景概述

该数据集包含斑马鱼视顶盖胶质细胞在不同发育阶段和TBI条件下的单细胞转录组测序数据，旨在揭示胶质细胞在生理和损伤条件下的时间异质性。数据覆盖从幼虫到成年多个发育阶段，并包括二次损伤后的测序结果，为研究胶质细胞在发育和损伤中的功能提供了重要资源。