Quantitative SIMS imaging analysis of boron concentrationsa from cis-ABCPC in F98 rat glioma brain tissue regions.

aBoron concentrations are expressed in µg/g wet weight (mean ± SD) in the main tumor mass (TM) and infiltrating clusters of tumor satellite cells (TS) and individual tumor cells (TC) in the normal brain tissue (BT) of F98 glioma bearing rats. The rats were treated with cis-ABCPC, as a mixture of its L- and D- enantiomers, with boron equivalent of 250 mg/kg b.w. i.p. for 2.5 hr. The observations represent the sampling of brain tissues from 3 rats and SIMS analysis in 6 imaging fields, as shown in Fig. 4.b,c,ddenote boron concentrations significantly (p