Iridium-Catalyzed Regio- and Enantioselective C7-Allylic Alkylation of 4‑Aminoindoles

The first iridium-catalyzed direct intermolecular indole
C7-allylic
alkylation of 4-aminoindoles and racemic branched allylic esters was
reported. Various substituted substrates were applicable to give the
corresponding C7-allylated products in moderate to high yields (43–80%)
with high regio- and enantioselectivities (82–99% ee) under
mild reaction conditions. Representative transformations of the vinyl
group in the product were carried out to examine the utility of this
protocol.