X-ray structure of HCAN_0200, an aminotransferase from Helicobacter canadensis in complex with its external aldimine

X-ray structure of HCAN_0200, an aminotransferase from Helicobacter canadensis in complex with its external aldimine Descriptor: (2R,3R,4S,5S,6R)-3,5-dihydroxy-4-{[(1E)-{3-hydroxy-2-methyl-5-[(phosphonooxy)methyl]pyridin-4-yl}methylidene]amino}-6-methyltetrahydro-2H-pyran-2-yl [(2R,3S,5R)-3-hydroxy-5-(5-methyl-2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-2-yl]methyl dihydrogen diphosphate, 1,2-ETHANEDIOL, CHLORIDE ION, ... Authors: Griffiths, W.A, Heisdorf, C.J, Thoden, J.B, Holden, H.M. Deposit date: 2021-06-07 Release date: 2021-06-23 Last modified: 2023-10-18 Method: X-RAY DIFFRACTION (1.4 Å) Cite: Investigation of the enzymes required for the biosynthesis of an unusual formylated sugar in the emerging human pathogen Helicobacter canadensis. Protein Sci., 30, 2021

加拿大螺杆菌（Helicobacter canadensis）来源的氨基转移酶（aminotransferase）HCAN_0200与其外部醛亚胺（external aldimine）复合物的X射线晶体结构。配体描述：(2R,3R,4S,5S,6R)-3,5-二羟基-4-{[(1E)-{3-羟基-2-甲基-5-[(膦酰氧基)甲基]吡啶-4-基}亚甲基]氨基}-6-甲基四氢-2H-吡喃-2-基 [(2R,3S,5R)-3-羟基-5-(5-甲基-2,4-二氧代-3,4-二氢嘧啶-1(2H)-基)四氢呋喃-2-基]甲基二氢二磷酸酯、1,2-乙二醇、氯离子……作者：格里菲斯（Griffiths, W.A）、霍伊斯多夫（Heisdorf, C.J）、托登（Thoden, J.B）、霍尔登（Holden, H.M）。沉积日期：2021-06-07；发布日期：2021-06-23；最后修改日期：2023-10-18。实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.4埃（Å）。引用文献：《探究新兴人类病原体加拿大螺杆菌中一种罕见甲酰化糖生物合成所需的酶》，发表于《蛋白质科学》（Protein Science），2021年，第30卷。