EXTRACTION OF BIOACTIVE COMPOUNDS OF LEAVES OF Duguetia furfuracea (ANNONACEAE) USING GREEN AND ORGANIC SOLVENTS

ABSTRACT Duguetia furfuracea (Annonaceae) is a shrub found in the Brazilian Cerrado that is used in popular medicine as an antirheumatic, for wound healing, treatment of kidney pain and against pediculosis. The aim of this study was to analyze the extraction of leaves of Duguetia furfuracea, using supercritical CO2, ethanol and hexane as solvents. For the supercritical extraction, an experimental planning 23 with triplicates of the central point was used to evaluate the effects of temperature (313-333 K), pressure (15-23 MPa) and volumetric flow rate (3-6 mL min-1) on the extraction yield, total phenolic content and antioxidant activity compared with extracts obtained by Soxhlet extraction. The effects of the variables on the extraction yield were positive and the pressure had greater influence. However, the highest performances, total phenolic content and antioxidant activities were obtained by the Soxhlet method. The mathematical model based on the Brunauer-Emmett-Teller theory of adsorption correlated satisfactorily the experimental values of the supercritical extraction.