Papain bound to a natural cysteine protease inhibitor from Streptomyces mobaraensis

Papain bound to a natural cysteine protease inhibitor from Streptomyces mobaraensis Descriptor: (2~{R})-2-[[(1~{S})-1-[(6~{S})-2-azanyl-1,4,5,6-tetrahydropyrimidin-6-yl]-2-[[(2~{S})-3-methyl-1-oxidanylidene-1-[[(2~{S})-1-oxidanyl-3-phenyl-propan-2-yl]amino]butan-2-yl]amino]-2-oxidanylidene-ethyl]carbamoylamino]-3-(4-hydroxyphenyl)propanoic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Papain Authors: Kraemer, A, Juettner, N.E, Fuchsbauer, H.-L, Edwards, A.M, Arrowsmith, C.H, Bountra, C, Knapp, S, Structural Genomics Consortium (SGC) Deposit date: 2019-11-06 Release date: 2019-12-04 Last modified: 2024-10-09 Method: X-RAY DIFFRACTION (1.65 Å) Cite: Decoding the Papain Inhibitor from Streptomyces mobaraensis as Being Hydroxylated Chymostatin Derivatives: Purification, Structure Analysis, and Putative Biosynthetic Pathway. J.Nat.Prod., 83, 2020

结合茂原链霉菌（Streptomyces mobaraensis）来源天然半胱氨酸蛋白酶抑制剂的木瓜蛋白酶（Papain）
描述符：(2R)-2-[[(1S)-1-[(6S)-2-氨基-1,4,5,6-四氢嘧啶-6-基]-2-[[(2S)-3-甲基-1-氧代-1-[[(2S)-1-羟基-3-苯基丙-2-基]氨基]丁-2-基]氨基]-2-氧代乙基]氨基甲酰氨基]-3-(4-羟苯基)丙酸、4-(2-羟乙基)-1-哌嗪乙磺酸、木瓜蛋白酶
作者：Kraemer, A、Juettner, N.E、Fuchsbauer, H.-L、Edwards, A.M、Arrowsmith, C.H、Bountra, C、Knapp, S、结构基因组学联盟（SGC）
提交日期：2019-11-06
发布日期：2019-12-04
最后修改日期：2024-10-09
实验方法：X射线衍射（分辨率1.65埃）
引用文献：《解码茂原链霉菌来源的木瓜蛋白酶抑制剂为羟化糜蛋白酶衍生物：纯化、结构分析及潜在生物合成途径》，《天然产物杂志》（J.Nat.Prod.），83卷，2020年