Gene expression analysis of hyper active mutant SPORTS rat [brain]

To get insight into the genetic characteristics of hyper active mutant line of rat, SPORTS, we compared gene expression profiles of the sedentary SPORTS rat and the sedentary wild type rat. Using RNA extracted from the brain of these rats, we performed microarray analysis. Subsequent GO analyses revealed that genes belonging to norepinephrine synthetic pathway and coagulation were upreguated. These results were consistent with phenotypes, such as hyper activity and thrombotic tendency, which were reported for SPORTS rat. Gene expression was measured using RNA, prepared from the brain of three sedentary SPORTS rats and that of three sedentary wild type rats.