Differential Co-Expression between α-Synuclein and IFN-γ Signaling Genes across Development and in Parkinson’s Disease
收藏Figshare2016-01-15 更新2026-04-29 收录
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https://figshare.com/articles/dataset/_Differential_Co_Expression_between_945_Synuclein_and_IFN_947_Signaling_Genes_across_Development_and_in_Parkinson_8217_s_Disease_/1266748
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Expression patterns of the alpha-synuclein gene (SNCA) were studied across anatomy, development, and disease to better characterize its role in the brain. In this postmortem study, negative spatial co-expression between SNCA and 73 interferon-γ (IFN-γ) signaling genes was observed across many brain regions. Recent animal studies have demonstrated that IFN-γ induces loss of dopamine neurons and nigrostriatal degeneration. This opposing pattern between SNCA and IFN-γ signaling genes increases with age (rho = −0.78). In contrast, a meta-analysis of four microarray experiments representing 126 substantia nigra samples reveals a switch to positive co-expression in Parkinson’s disease (p
创建时间：
2016-01-15
