miRnalyze

miRnalyze is an online web based tool that has been developed to analysed the putative regulation of cell signaling pathways by microRNAs. Genes and pathways data have been adapted from Kyoto Encyclopedia of Genes and Genomes (KEGG) database . MicroRNA target prediction data are retrieved from TargetScanHuman 7.1 target prediction tool. miRnalyze predicts putative miRNA targets in cellular signaling pathways directly through identifying involved genes in those pathways. Additionally, it provides users with the ability to identify common miRNAs that have more than one target in the signal transduction pathways – a feature that is unique to miRnalyze. Further, the tool allows users to sort the enlisted miRNAs based on their type of seed matches and the TargetScan Context++ score. The results thereby displayed in a hierarchy of manner allowing user to identify most relevant miRNAs on top of the lists. The above mentioned features have the potentiality to help researchers to choose for the most favorable miRNAs for expression profiling experiments.miRnalyze是一款基于网页的在线工具，专为分析微小RNA（microRNAs）对细胞信号通路的潜在调控作用而开发。其基因与通路数据改编自京都基因与基因组百科全书（Kyoto Encyclopedia of Genes and Genomes, KEGG）数据库，miRNA靶标预测数据来源于TargetScanHuman 7.1靶标预测工具。miRnalyze可通过识别细胞信号通路中的关联基因，直接预测这些通路中的潜在miRNA靶标。此外，该工具支持用户筛选出在信号转导通路中拥有多个靶标的共有miRNA，这是miRnalyze独有的功能特性。用户还可基于种子匹配类型与TargetScan Context++评分，对已列出的miRNA进行排序，最终结果将以层级化方式呈现，使用户可在列表顶端快速定位最具相关性的miRNA。上述功能可助力研究人员筛选出最适用于表达谱实验的miRNA。

搜集汇总

背景与挑战

背景概述

miRnalyze是一个基于网络的在线工具，旨在分析microRNA对细胞信号通路的潜在调控作用。它整合了KEGG数据库的通路和基因数据以及TargetScanHuman的靶点预测信息，能够识别信号通路中的miRNA靶点，并提供共同miRNA发现及排序功能，覆盖了多种生物信号通路。