Treatment with MK-886 does not influence anxiety-like behavior in the EPM test.
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Mice were treated with MK-886 via i.p. or i.c.v. route and tested on the EPM. There was no significant difference in anxiety-like behavior among groups in either mouse strain (Swiss or C57BL/6) or administration route (i.p. or i.c.v.). AM251, a CB1 antagonist, was used as positive control. Data are presented as Mean ± SEM. Statistical analysis was carried out by ANOVA followed by Duncan’s post hoc test. p<0.05 vs vehicle. p<0.01 vs vehicle.
创建时间：
2014-01-08
