Dietary bile acid influences the physiological, morphological, molecular responses and transcriptomic profile of hepatopancreas in juvenile gibel carp (Carassius auratus gibelio) fed high-fat diet

To assess the influence of dietary bile acid (BA) on the phenotype associated with hepatic lipid metabolism and its regulation of lipid homeostasis in high fat diet (HFD) fed gibel carp (Carassius auratus gibelio), five HFD diets were designed by using soybean oil (SO) as the single lipid source and supplemented with 0, 200, 400, 600, and 800 mg/kg BA (designated as BA0, BA200, BA400, BA600, and BA800), respectively. Juvenile fish were fed five BA added HFD diets for 8 weeks.