Direct Catalytic Asymmetric Aldol Reaction of α‑Vinyl Acetamide
收藏NIAID Data Ecosystem2026-03-10 收录
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A direct catalytic asymmetric aldol addition of an α-vinyl 7-azaindoline amide to both aromatic and aliphatic aldehydes was promoted by a cooperative acid/base catalyst in a stereodivergent manner. The key structural element, a 7-azaindoline moiety, facilitated catalytic enolization, allowing for subsequent stereoselective aldol addition. Enantioselective synthesis of the key intermediate of blumiolide C and kainic acid supported the synthetic utility of this protocol.
创建时间：
2018-05-02
