Cytotoxicity and anti-HSV-2 activity of tannic acid-modified 13, 33, 46 nm AgNPs, unmodified 10–65 nm AgNPs or corresponding carriers in 291.03C cells.*

* The values shown are means from three independent experiments with each treatment performed in triplicate.†Cytotoxic effects were evaluated by neutral red assay to determine the concentration of 50% cellular cytotoxicity (CC50) of the tested compounds.‡Antiviral effects were evaluated by plaque assay to determine the effective concentration that achieved 50% inhibition (EC50) against HSV-2 infection.§SI. selectivity index.CC50/EC50.