Epitope specific paired TCR repertoire sequencing

The aim of the project to identify the features of epitope-specific T cell receptor repertoires that confer specificity and present an analytical approach for quantifying the deterministic traits of any TCR sequence. Due to the unique features of TCR biology (e.g., paired chain receptor, the wide diversity of TCR regions, the variable importance of residues with the CDR3s and their variation in lengths) this has been a challenging problem for the field. Our work relies on a large, novel data set of paired aß TCR sequences of known antigen-specificity that allow us to infer the critical attributes of TCR sequences that mediate antigen-recognition.