NNI Supplement to the President's 2011 Budget
收藏国家科技图书文献中心2026-05-09 收录
下载链接：
http://portal.nstl.gov.cn/reportFront/getReportDetailFront.htm?serverId=12&uuid=ef6c614ac49eb09bea4f58f030944fe7
下载链接
链接失效反馈官方服务：
资源简介：
Centralimage:Adarkfieldopticalmicroscopeimageofbreastcancercellswithgoldnanopyramidsattachedtothecellsurfacesbyantibodiesonthenanopyramids.Becauseofthetargetingprovidedbytheantibodies,thegoldnanoparticlescanbeusedasbothlocalizedtherapeuticagentsanddiagnosticprobes.Thepyramidsareabout200nanometersattheirbaseandtapertoabout1nanometerattheirtips.Intheimageshown,thegoldnanopyramidsappearasbrightorangespots.Thecellsareabout10micrometersindiameter.Thenanoparticlescanbehaveashighcontrastprobestoidentifycancercellsandtovisualizethelocationofbiomarkers.Whenilluminatedwithnear-infraredlight,thenanopyramidsgenerateheatthatcanbeusedtolocallydestroycancercelswithoutharmingthesurroundinghealthycells.Theultra-sharptipandedgesofthenanopyramidsproducehighlyconcentratedelectromagneticfieldsthatcanfurtherenhancetheirheatingabilities(workfundedbyNIHNCIAllianceforNanotechnologyinCancerandNIHDirector’sPioneerAward;courtesyofTeriW.Odom,NorthwesternUniversity,http://chemgroups.northwestern.edu/odom/andThomasV.O’Halloran,NorthwesternUniversity,http://chemgroups.northwestern.edu/ohalloran/).Backgroundimage:False-colorscanningelectronmicroscopyimageofthegoldnanopyramidssituatedonsiliconpedestalsastheyareformedusinghigh-resolutionlithography;thespacingofthepedestalsisabouttwomicrometers.Thisimagedemonstrateshowanisotropicparticlesmadebynanofabricationmethodsarehighlyuniforminsizeandcanbethree-dimensionalinshape.Themethodalsoenablesselectivefunctionalizationofthenanoparticlesurfaces(workfundedbyNSF;courtesyofTeriW.Odom).
提供机构：
美国国家纳米科技倡议
