Activity-dependent gene expression in the human brain

We report a bulk transcriptomic dataset and a multiomic dataset of human anterior temporal lobe to identify gene expression changes and epigenetic signatures after electrical stimulation. We also report a bulk transcriptomic dataset of mouse auditory cortex. We performed bulk RNA sequencing gene expression analysis obtained from human anterior temporal lobe for two paradigms: the stimulated paradigm (subject4-7 stimulated vs. subject4-7 baseline) and the unstimulated paradigm (unstimulated vs baseline). We performed multiomic sequencing (snRNA-seq + snATAC-seq) obtained from from human anterior temporal lobe of 2 groups (stimulated4B+5B+6B vs. baseline4A+5A+6A). We also performed bulk RNA sequencing gene expression analysis obtained from mouse auditory cortex for the stimulated paradigm (samples 1, 2, 5 and 7).