YAP and AP-1 cooperate to initiate rapid pancreatic cancer development from the ductal cell population in mice
收藏NIAID Data Ecosystem2026-03-12 收录
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE129045
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Purpose: We aimed to elucidate the unique consequences of YAP/TAZ activation in pancreatic ductal cells. Methods: We isolated RNA from Lats1 and Lats2 double knockout ductal cells from Lats1fl/fl; Lats2fl/fl; Sox9-CreER mice. Results: Oncogenic activation of YAP in ductal cells lead to the rapid development of carcinoma in situ with microinvasion. mRNA profiles of pancreatic duct cells from control and Lats1/2 knockout mice were created by mRNA-sequencing.
创建时间：
2020-09-20
