Blockade of menthol’s effects on nicotine acute pharmacological responses after administration in mice.

*p #p Animals were pretreated with either saline or mecamylamine (2 mg/kg, s.c.) followed by menthol (100 mg/kg, i.p.). Thirty min later, mice received nicotine at a dose of 2.5 mg/kg (s.c.) and were then tested 45 min after injection. Menthol = menthol at 100 mg/kg, i.p.; Mec: Mecamylamine at 2 mg/kg, s.c.; Nic: Nicotine at 2.5 mg/kg, s.c.; Sal: Saline; Veh: vehicle. Each point represents the mean ± SE of 8 to 10 mice