RNA seq of MRTX849 parental and resistant cells treated with vehicle and MRTX849. RNA seq of MRTX849 parental and resistant cells treated with vehicle and MRTX849

To determine the difference between MRTX849 parental and resistant cells in response to MRTX849 treatment, we used high-throughput next-generation sequencing technology to compare transcriptomics between parental and MRTX849-resistant MIA PaCa-2 cells that were cultured in the absence or presence of MRTX849 (1 uM, 4h).