官方服务:
资源简介:
Off-target analysis of IL2RG gene mutation corrected by ABE8e
应用场景:
创建时间:
2024-04-09
相关数据集
A Type II-B Cas9 nuclease with no detectable off-targets and reduced chromosomal translocations in vivo.
Streptococcus pyogenes Cas9 (SpCas9) and derived enzymes are widely used as components of CRISPR-Cas9 genome editing and engineering platforms. However, they exhibit promiscuous nuclease activity that
NIAID Data Ecosystem60
In vivo evaluation of guide-free Cas9 induced genomic damage and transcriptome changes using pig models (RNA-seq). Sus scrofa
The CRISPR/Cas9 system is currently the most promising tool for treating human genetic diseases, several of which have been evaluated in clinical trials with anticipated beneficial effects. Significan
NIAID Data Ecosystem50
In vivo genome editing using novel AAV-PHP variants rescues motor function deficits and extends survival in a SOD1-ALS mouse model
CRISPR-based gene editing technology represents a promising approach to deliver therapies for inherited disorders, including amyotrophic lateral sclerosis (ALS). Toxic gain-of-function superoxide dism
NIAID Data Ecosystem10
Deep sequencing of 8 off-target sites detected by WGS
We successfully develop a two-in-one approach to generate non-viral genome specific targeted CAR T cells through CRISPR/Cas9. In the adoptive therapy for relapsed/refractory aggressive B-cell non-Hodg
NIAID Data Ecosystem50
A Cas-Embedding Strategy for Minimizing Off-Target Effects of DNA Base Editors. Homo sapiens
A Cas-Embedding Strategy for Minimizing Off-Target Effects of DNA Base Editors
NIAID Data Ecosystem30



