Ageing signatures in NSG mice. Ageing signatures in NSG mice

Purpose: Understanding the role of an active immunesystem in ageing. Methods: Male NSG (NOD scid gamma) immunodeficient mice were maintained in normal housing condition. Islet cells were isolated at different age points and mRNA were extracted before shipping to Qiagen for analysis. Results: In NSG mice multiple of the metabolic pathways that are observed to be deregulated in ageing immunocompotent mice are infered to be sustained. Overall design: mRNA from pancreatic islets from NSG mice at 6, 12, 24, and 40 weeks of age