Crystal structure of Bcl-xL in complex with inhibitor (Compound 2).

Crystal structure of Bcl-xL in complex with inhibitor (Compound 2). Descriptor: BCL-2-LIKE PROTEIN 1, N-(3-(5-(1-(2-(benzo[d]thiazol-2-yl)hydrazono)ethyl)furan-2-yl)phenylsulfonyl)-6-phenylhexanamide Authors: Czabotar, P.E, Lessene, G.L, Smith, B.J, Colman, P.M. Deposit date: 2013-01-22 Release date: 2013-04-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (2.48 Å) Cite: Structure-Guided Design of a Selective Bcl-Xl Inhibitor Nat.Chem.Biol., 9, 2013B细胞淋巴瘤因子xL（Bcl-xL）与抑制剂（化合物2）结合的晶体结构。描述项：B细胞淋巴瘤因子2样蛋白1（BCL-2-LIKE PROTEIN 1），N-(3-(5-(1-(2-(苯并[d]噻唑-2-基)腙基)乙基)呋喃-2-基)苯磺酰基)-6-苯基己酰胺。作者：Czabotar P.E.、Lessene G.L.、Smith B.J.、Colman P.M.。提交日期：2013-01-22。发布日期：2013-04-24。最后修改日期：2023-12-20。实验方法：X射线衍射（分辨率2.48埃）。引用文献：《选择性Bcl-xL抑制剂的结构导向设计》，《自然·化学生物学》，9卷，2013年