STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE IN COMPLEX WITH INHIBITOR COMPOUND (4R,6R,7S)-4,6,7-Trihydroxy-2-((E)-prop-1- enyl)-4,5,6,7-tetrahydrobenzo(b)thiophene-4-carboxylic acid

STRUCTURE OF HELICOBACTER PYLORI TYPE II DEHYDROQUINASE IN COMPLEX WITH INHIBITOR COMPOUND (4R,6R,7S)-4,6,7-Trihydroxy-2-((E)-prop-1- enyl)-4,5,6,7-tetrahydrobenzo(b)thiophene-4-carboxylic acid Descriptor: (4R,6R,7S)-4,6,7-TRIHYDROXY-2-[(1E)-PROP-1-EN-1-YL]-4,5,6,7-TETRAHYDRO-1-BENZOTHIOPHENE-4-CARBOXYLIC ACID, 3-DEHYDROQUINATE DEHYDRATASE Authors: Paz, S, Tizon, L, Otero, J.M, Llamas-Saiz, A.L, Fox, G.C, van Raaij, M.J, Lamb, H, Hawkins, A.R, Lapthorn, A.J, Castedo, L, Gonzalez-Bello, C. Deposit date: 2010-04-30 Release date: 2010-11-24 Last modified: 2023-12-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Tetrahydrobenzothiophene derivatives: conformationally restricted inhibitors of type II dehydroquinase. ChemMedChem, 6, 2011

幽门螺杆菌（Helicobacter pylori）II型脱氢奎尼酸酶与抑制剂(4R,6R,7S)-4,6,7-三羟基-2-((E)-丙-1-烯基)-4,5,6,7-四氢苯并[b]噻吩-4-羧酸复合物的晶体结构。复合物描述：配体为(4R,6R,7S)-4,6,7-三羟基-2-[(1E)-丙-1-烯-1-基]-4,5,6,7-四氢-1-苯并噻吩-4-羧酸，该酶为3-脱氢奎尼酸脱水酶（3-dehydroquinate dehydratase）。作者：Paz S、Tizon L、Otero J.M.、Llamas-Saiz A.L.、Fox G.C.、van Raaij M.J.、Lamb H、Hawkins A.R.、Lapthorn A.J.、Castedo L、Gonzalez-Bello C.。存库日期：2010年4月30日；发布日期：2010年11月24日；最后修改日期：2023年12月20日。实验方法：X射线衍射（分辨率1.95 Å）。引用文献：《四氢苯并噻吩衍生物：II型脱氢奎尼酸酶的构象限制性抑制剂》，ChemMedChem，第6卷，2011年。