Massively parallel engineering of persistent CAR-Ts [XDRNA]
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE207404
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To evaluate the immunological landscape of PRDM1-crRNA CAR-Ts, we performed timecourse RNAseq. We also compared and contrasted transcription profiles of CAR-Ts mutated by two different PRDM1-crRNAs. T cells were infected with CLASH vector and PRDM1-cr1 CAR22 AAV6 after electroporation with NLS6 LbCpf1mRNA. For time course data, resulting PRDM-1 edited CAR-Ts were then subject to coculture; RNA at different time points was collected and libraries were prepared. For the PRDM1-cr1 vs. PRDM2 experiment, one time point was used.
创建时间：
2022-12-12
