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GBA1 interactome for understanding pathological mechanisms

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NIAID Data Ecosystem2026-05-01 收录
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Compound heterozygous or homozygous GBA1 mutations lead to Gaucher disease. Furthermore, GBA1 mutations are the most frequent risk factor for Parkinson’s disease. To get a better understanding of the pathological mechanisms, we generated inducible V5-Flag-Tag, V5-Flag-tagged WT, E326K and L444P mutant Flp-In™T-REx™-HEK293 and performed interatomic analysis.

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2023-05-10
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