Single-Cell Transcriptomics of Genome-Edited Kidney Organoids
收藏干细胞与再生医学数据中心2022-02-20 更新2024-03-06 收录
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http://data.iscr.ac.cn/Article?id=053f836d79a4ade04ccf412ddc31c445
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资源简介：
We report the first use of genome-edited human kidney organoids, combined with single-cell transcriptomics, to study APOL1 risk variants at the native genomic locus in different nephron cell types. This approach captures interferon-mediated induction of APOL1 gene expression and cellular dedifferentiation with a secondary insultâsecond hitâ of endoplasmic reticulum stress.
提供机构：
Northwestern University
创建时间：
2022-02-20
