Structure of P. aeruginosa LpxC with compound 10: (2RS)-4-(5-(2-Fluoro-4-methoxyphenyl)-1-oxoisoindolin-2-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide

Structure of P. aeruginosa LpxC with compound 10: (2RS)-4-(5-(2-Fluoro-4-methoxyphenyl)-1-oxoisoindolin-2-yl)-N-hydroxy-2-methyl-2-(methylsulfonyl)butanamide Descriptor: (2~{R})-4-[6-(2-fluoranyl-4-methoxy-phenyl)-3-oxidanylidene-1~{H}-isoindol-2-yl]-2-methyl-2-methylsulfonyl-~{N}-oxidanyl-butanamide, (2~{S})-4-[6-(2-fluoranyl-4-methoxy-phenyl)-3-oxidanylidene-1~{H}-isoindol-2-yl]-2-methyl-2-methylsulfonyl-~{N}-oxidanyl-butanamide, UDP-3-O-acyl-N-acetylglucosamine deacetylase, ... Authors: Surivet, J.-P, Panchaud, P, Specklin, J.-L, Diethelm, S, Blumstein, A.-C, Gauvin, J.-C, Jacob, L, Masse, F, Mathieu, G, Mirre, A, Schmitt, C, Enderlin-Paput, M, Lange, R, Bur, D, Tidten-Luksch, N, Gnerre, C, Seeland, S, Hermann, C, Locher, H.H, Seiler, P, Mac Sweeney, A, Hubschwerlen, C, Ritz, D, Rueedi, G. Deposit date: 2018-11-09 Release date: 2019-12-18 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Discovery of Novel Inhibitors of LpxC Displaying Potent in Vitro Activity against Gram-Negative Bacteria. J.Med.Chem., 63, 2020

铜绿假单胞菌（P. aeruginosa）LpxC与化合物10的复合物结构：(2RS)-4-(5-(2-氟-4-甲氧基苯基)-1-氧代异吲哚啉-2-基)-N-羟基-2-甲基-2-(甲磺酰基)丁酰胺。相关描述包括：(2R)-4-[6-(2-氟-4-甲氧基苯基)-3-氧代-1H-异吲哚-2-基]-2-甲基-2-甲磺酰基-N-羟基丁酰胺、(2S)-4-[6-(2-氟-4-甲氧基苯基)-3-氧代-1H-异吲哚-2-基]-2-甲基-2-甲磺酰基-N-羟基丁酰胺，以及UDP-3-O-酰基-N-乙酰葡糖胺脱乙酰酶（UDP-3-O-acyl-N-acetylglucosamine deacetylase）。作者列表：Surivet, J.-P、Panchaud, P、Specklin, J.-L、Diethelm, S、Blumstein, A.-C、Gauvin, J.-C、Jacob, L、Masse, F、Mathieu, G、Mirre, A、Schmitt, C、Enderlin-Paput, M、Lange, R、Bur, D、Tidten-Luksch, N、Gnerre, C、Seeland, S、Hermann, C、Locher, H.H、Seiler, P、Mac Sweeney, A、Hubschwerlen, C、Ritz, D、Rueedi, G。存档日期：2018-11-09；发布日期：2019-12-18；最后修改日期：2024-01-24。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率1.9 Å）。引用文献：《发现对革兰氏阴性菌具有强效体外活性的新型LpxC抑制剂》，刊载于《药物化学杂志（J.Med.Chem.）》第63卷，2020年。