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Context-specific roles of diphthamide deficiency in hepatocellular carcinogenesis

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NIAID Data Ecosystem2026-03-13 收录
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In our current study, we observed that in hepatic carcinogen diethylnitrosamine (DEN)-induced liver tumor mouse model, diphthamide-deficient mouse developed less liver tumor incidence than control mouse. To explore the detailed mechanism, RNA-seq experiment was conducted to compare gene transcriptome profiles of control and diphthamide-deficient livers during HCC progression. Overall design: Comparison of liver tissue transcriptomes in control (2 samples) and Dph1 KO livers (2 samples) at 1-day (1D) post-DEN treatment

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2021-12-21
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