Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties
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https://figshare.com/articles/dataset/Discovery_Development_and_SAR_of_Aminothiazoles_as_LIMK_Inhibitors_with_Cellular_Anti_Invasive_Properties/2118727
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资源简介：
As
part of a program to develop a small molecule inhibitor of LIMK,
a series of aminothiazole inhibitors were discovered by high throughput
screening. Scaffold hopping and subsequent SAR directed development
led to a series of low nanomolar inhibitors of LIMK1 and LIMK2 that
also inhibited the direct biomarker p-cofilin in cells and inhibited
the invasion of MDA MB-231-luc cells in a matrigel inverse invasion
assay.
创建时间：
2016-02-12
