PI103 sensitizes HT1080 cells to DOX-induced apoptosis.

Proliferation of HT1080 cells was measured by BrdU incorporation. Shown is the increase or decrease in comparison to vehicle-treated cells. Apoptosis was analyzed by FACS of Annexin V positive cells and caspase 3/7 activity was measured by Caspase-Glo® 3/7 assay. Statistical significance was assessed by ANOVA/Tukey’s method. *P<0.05 compared to cells treated with solvent; #P<0.05 compared to cells treated with either drug alone. Numbers in bold indicate cases, where given drug combination inhibited proliferation or induced apoptosis to a larger extent than either drug alone.