Nickel-Catalyzed Cyclization of 2-Iodoanilines with Aroylalkynes: An Efficient Route for Quinoline Derivatives

An efficient and convenient nickel-catalyzed cyclization of
2-iodoanilines with alkynyl aryl ketones to give 2,4-disubstituted quinolines was developed. The reaction can be
employed for the synthesis of naturally occurring quinoline
derivatives in good yields. On the basis of the regiochemistry
of the products, the possible pathway for the reaction is via
the formation of o-aminochalcone.