Understanding the contribution of abnormal genetic and epigenetic programs to acute myeloid leukemia (AML) is necessary for the integrated design of targeted therapies. To investigate this, we determi

NIAID Data Ecosystem40

The acute myeloid leukemia associated AML1-ETO fusion protein alters the transcriptome and cellular progression in a single-oncogene expressing in vitro induced pluripotent stem cell based granulocyte differentiation model

白血病干细胞模型

粒细胞分化

Acute myeloid leukemia (AML) is characterized by recurrent mutations that affect normal hematopoiesis. The analysis of human AMLs has mostly been performed using end-point materials, such as cell line

Figshare2019-12-23 更新10

Expression profiling of murine leukemia stem cell (LSC) lines established ex vivo by coexpression of R882H-mutated DNMT3A and NRAS-G12D post treatment with Dot1l inhibitor (Microarray). Mus musculus

白血病干细胞模型

表观遗传学

DNA Methyltransferase 3A (DNMT3A) is frequently mutated in various hematopoietic malignancies; however, the underlying oncogenic mechanisms remain elusive. Here, we report that DNMT3A mutational ‘hots

NIAID Data Ecosystem50

RNA-seq as a global measure of the similarity between human pluripotent stem cell and fetal liver derived B cell hierarchies. RNA-seq as a global measure of the similarity between human pluripotent stem cell and fetal liver derived B cell hierarchies

白血病干细胞模型

血细胞发育转录组学

Evidence suggests childhood acute lymphoblastic leukemia (cALL) arises in early human development. Existing models of pre-leukemic initiation using the ETV6-RUNX1 fusion do not recapitulate human dise

NIAID Data Ecosystem30

A human ESC model for MLL-AF4 reveals an impaired early human hemato-endothelial specification

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