Primary mucosal melanoma (MM), which arise from melanocytes located in mucosal membranes, frequently present late and have a poor prognosis; ~14% 5-year survival rate. MM makes up only ~1.4% of all me
We performed CRISPR screens on both a sub-library and a genome-wide scale in human intestinal organoids to discover cancer driver genes. We investigated the Wnt and the TGFB pathway and used both WT,