Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution in a ternary complex with fragment compounds 5-methoxyindole and 1-benzofuran-2-carboxylic acid

Crystal Structure of Mycobacterium Tuberculosis Pantothenate Synthetase at 1.8 Ang resolution in a ternary complex with fragment compounds 5-methoxyindole and 1-benzofuran-2-carboxylic acid Descriptor: 1-benzofuran-2-carboxylic acid, 5-methoxy-1H-indole, ETHANOL, ... Authors: Ciulli, A, Hung, A.W, Silvestre, H.L, Wen, S, Blundell, T.L, Abell, C. Deposit date: 2009-08-10 Release date: 2009-10-13 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.8 Å) Cite: Application of fragment growing and fragment linking to the discovery of inhibitors of Mycobacterium tuberculosis pantothenate synthetase. Angew.Chem.Int.Ed.Engl., 48, 2009

分辨率为1.8埃的结核分枝杆菌（Mycobacterium Tuberculosis）泛酸合成酶（Pantothenate Synthetase）与片段化合物5-甲氧基吲哚（5-methoxyindole）及1-苯并呋喃-2-羧酸（1-benzofuran-2-carboxylic acid）形成的三元复合物晶体结构。配体描述：1-苯并呋喃-2-羧酸、5-甲氧基-1H-吲哚、乙醇（ETHANOL）等。作者：Ciulli, A、Hung, A.W、Silvestre, H.L、Wen, S、Blundell, T.L、Abell, C。提交日期：2009-08-10；发布日期：2009-10-13；最后修改日期：2023-09-06。实验方法：X射线衍射（X-RAY DIFFRACTION），解析分辨率1.8 Å。引用文献：《基于片段生长与片段连接策略发现结核分枝杆菌泛酸合成酶抑制剂》，Angew.Chem.Int.Ed.Engl., 48, 2009。