Type2_Simeonov_distr_1212_15_15_1_Enhancers

NIAID Data Ecosystem2026-03-11 收录

CRISPRi筛选

增强子识别

数据链接：

https://figshare.com/articles/dataset/Type2_Simeonov_distr_1212_15_15_1_Enhancers/8251472 数据链接链接失效反馈

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资源简介：

Enhancer positions from simulated CRISPR regulatory screen. Type 2, medium guide counts, low selection strength

创建时间：

2019-06-20

raw data for main figures.xlsx

CRISPRi筛选

功能基因组学

data used to create main figures for: Park et. al., Efficient prioritization of CRISPR screen hits by accounting for targeting efficiency of guide RNA, BMC Biol, 2023.

Figshare2023-01-28 更新70

Genome-scale CRISPRi Perturb-seq on both unstimulated and stimulated Jurkat cells reveals regulators of human T-cell signaling

T细胞信号传导调控

CRISPRi筛选

The goal of the experiment is to identify genes involved in T-cell receptor (TCR) signaling and T-cell activation in human T cells. The Jurkat E6 cell line, engineered to express dCas9-KRAB and transd

NIAID Data Ecosystem20

Genes of CRISPR-Cas9 negative screening.

CRISPRi筛选

肿瘤免疫逃逸

We compared changes in sgRNA abundance between T24 cells challenged and unchallenged by CD8+ T cells, and then performed negative screening (p < 0.01, log2Fold change < −1.0, and good sgRNAs ≥ 5). (X

NIAID Data Ecosystem10

Bcor loss perturbs myeloid differentiation and promotes leukaemogenesis [TargetedCRISPRscreen]

白血病发病机制

CRISPRi筛选

Investigating Bcor target genes in BcorΔE9-10KrasG12D leukaemia with a custom CRISPR dropout screen BcorΔE9-10KrasG12D cell line was transduced with a custom CRISPR library and a dropout screen was pe

NIAID Data Ecosystem30

Essential gene profiles for human pluripotent stem cells identify uncharacterized genes and substrate dependencies. Mair et al.

干细胞鉴定

CRISPRi筛选

Human pluripotent stem cells (hPSCs) provide an invaluable tool for modeling diseases and hold promise for regenerative medicine. For understanding pluripotency and lineage differentiation mechanisms,

NIAID Data Ecosystem20

Type2_Simeonov_distr_1212_15_15_1_Enhancers

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