Essential roles of Lamtor1 in CD4+ T cell-mediated autoimmunity
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https://www.ncbi.nlm.nih.gov/geo/query/acc.cgi?acc=GSE92946
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资源简介：
Lamtor1 is a protein that is required for amino acid sensing and activation of mechanistic target of rapamycin complex 1 (mTORC1) at lysosomes. The critical role of Lamtor1 in macrophage polarization has been clarified recently. However, the role of Lamtor1 in adaptive immune system has not been investigated. Here we show that Lamtor1-deficient T cells showed markedly reduced IL-2 production, decreased mTORC1 activity, and decreased expression of purine-synthesis and lipid-synthesis enzymes. The labeled cRNAs were hybridized on 4X44K ver.2 Agilent Whole Mouse Genome dual colour Microarrays (G4846A) in a dye swap experiment.
创建时间：
2018-01-19
