T7 DNA polymerase ternary complex with 8 oxo guanosine and dCMP at the elongation site

NIAID Data Ecosystem2026-05-01 收录

DNA氧化损伤

DNA复制保真度

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T7 DNA polymerase ternary complex with 8 oxo guanosine and dCMP at the elongation site

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2023-08-23

Theoretical Study of the Tautomerism in the One-Electron Oxidized Guanine−Cytosine Base Pair

DNA氧化损伤

异构化反应机理

Ionizing radiation on DNA mainly generates one-electron oxidized guanine−cytosine base pair (G+•:C), and in the present paper we study all possible tautomers of G+•:C by using ab initio approaches. Ou

NIAID Data Ecosystem80

Bacillus subtilis PY79 mutation accumulation lines. Bacillus subtilis PY79

微生物突变

DNA复制保真度

Mutation accumulation was carried out in strains with and without DNA mismatch repair to determine the effect of sequence context on DNA polymerase error rate in vivo.

NIAID Data Ecosystem70

Human DNA polymerase eta-DNA-rU-ended primer-dGMPNPP ternary mismatch complex with Mg2+

DNA聚合酶-底物复合物结构

DNA复制保真度

Human DNA polymerase eta-DNA-rU-ended primer-dGMPNPP ternary mismatch complex with Mg2+ Descriptor: 2'-deoxy-5'-O-[(R)-hydroxy{[(R)-hydroxy(phosphonooxy)phosphoryl]amino}phosphoryl]guanosine, DNA (5'-

Protein Data Bank Japan2023-10-25 更新30

A Reversible Histone H3 Acetylation Cooperates with Mismatch Repair and Replicative Polymerases in Maintaining Genome Stability

组蛋白乙酰化与突变抑制

DNA复制保真度

Mutations are a major driving force of evolution and genetic disease. In eukaryotes, mutations are produced in the chromatin environment, but the impact of chromatin on mutagenesis is poorly understoo

NIAID Data Ecosystem80

Human DNA polymerase epsilon is a source of C>T mutations at CpG dinucleotides

DNA复制保真度

突变谱分析

C to T transitions in CpG dinucleotides are the most prevalent mutations in human cancers and genetic diseases. This bias has been attributed to deamination of 5-methylcytosine (5mC), an epigenetic mo

NIAID Data Ecosystem40

T7 DNA polymerase ternary complex with 8 oxo guanosine and dCMP at the elongation site

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