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1.95 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic inhibitor

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Protein Data Bank Japan2024-11-20 更新2026-03-21 收录
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1.95 A resolution structure of Norovirus 3CL protease in complex with a triazole-based macrocyclic inhibitor Descriptor: 3C-like protease, benzyl [(9S,12S,15S)-12-(cyclohexylmethyl)-9-(hydroxymethyl)-6,11,14-trioxo-1,5,10,13,18,19-hexaazabicyclo[15.2.1]icosa-17(20),18-dien-15-yl]carbamate Authors: Lovell, S, Battaile, K.P, Mehzabeen, N, Kankanamalage, A.C.G, Weerawarna, P.M, Rathnayake, A.D, Kim, Y, Chang, K.O, Groutas, W.C. Deposit date: 2017-11-01 Release date: 2018-11-07 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (1.95 Å) Cite: Putative structural rearrangements associated with the interaction of macrocyclic inhibitors with norovirus 3CL protease. Proteins, 87, 2019

1.95 Å分辨率的诺如病毒3C样蛋白酶(Norovirus 3CL protease)与三唑基大环抑制剂的复合物晶体结构 描述条目:3C样蛋白酶,苄基[(9S,12S,15S)-12-(环己基甲基)-9-(羟甲基)-6,11,14-三氧代-1,5,10,13,18,19-六氮杂双环[15.2.1]二十碳-17(20),18-二烯-15-基]氨基甲酸酯 作者:Lovell S、Battaile K.P.、Mehzabeen N、Kankanamalage A.C.G、Weerawarna P.M.、Rathnayake A.D.、Kim Y、Chang K.O.、Groutas W.C. 存放日期:2017-11-01 发布日期:2018-11-07 最后修改日期:2024-11-20 实验方法:X射线衍射(X-RAY DIFFRACTION),分辨率1.95 Å 引用文献:《与大环抑制剂和诺如病毒3C样蛋白酶相互作用相关的推定结构重排》,《Proteins》,第87卷,2019年
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2017-11-01
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