Integration of cell-specific gene expression and chromatin accessibility facilitates localization of neurodegenerative risk

cis-QTL for differentiated fore-brain neurons (iFBn) and microglia (iMGL) cis-eQTL results - each archive contains the TensorQTL cis map csv and per chromosome parquet files iFBn_eQTL.tar.gz iMGL_eQTL.tar.gz cis-caQTL results - each archive contains the TensorQTL cis map csv and per chromosome parquet files iFBn_caQTL.tar.gz iMGL_caQTL.tar.gz Correlations of gene's and their cis-proximal ATAC peaks - each archive contains the TensorQTL cis map csv and per chromosome parquet files iMGL_gene-ATAC.tar.gz iFBn_gene-ATAC.tar.gz Meta-analyses of cis-eQTL for broad neuron types and microglia - meta-analyses of public post-mortem cell-type specific cis-eQTL and cis-eQTL from differentiated specific cell-types excitatory_meta_eqtl.parquet inhibitory_meta_eqtl.parquet microglia_meta_eqtl.parquet Meta-analyses post-mortem cell-type specific cis-eQTL, Byrois et al 2022 and ROSMAP cortical_astrocytes_meta_eqtl.parquet cortical_endothelial_meta_eqtl.parquet cortical_excitatory_meta_eqtl.parquet cortical_inhibitory_meta_eqtl.parquet cortical_microglia_meta_eqtl.parquet cortical_oligodendrocytes_meta_eqtl.parquet cortical_opc_meta_eqtl.parquet Colocalization scores of cis-eQTL, meta-cis-eQTL for specific cell-types, and public bulk cis-eQTL per brain region from MetaBrain for GWAS common neurodegenerative risk loci for Alzheimer's, Lewy Body Dementia, and Parkinson's disease. eqtl_coloc_scores.csv caqtl_coloc_scores.csv