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SW480 Signaling Hub Inhibition. Homo sapiens

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NIAID Data Ecosystem2026-03-07 收录
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA141107
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In tumor cells, stepwise oncogenic deregulation of signaling cascades induces alterations of cellular morphology and promotes the acquisition of malignant traits. Using a panel of small molecular inhibitors, we established associated gene expression signatures of key signaling hubs. Overall design: SW480 cells were grown in DMEM, 10% FCS, and treated for 24h with the following inhibitors or with solvent (DMSO): SU5402 (42uM); U0126 (10uM), SP600125 (20uM), LY294002 (20uM)
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2011-06-03
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