HIV-1 NL4-3 Gag mutants selected for testing of predicted energy costs (E) by an <i>in vitro</i> HIV-1 replication capacity assay.
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aEnergy cost predicted by original Ising model [11] taking into account differences in NL4-3 and the multiple sequence alignment used in model generation. E is 2.98 for wild-type NL4-3 p24 and 3.43 for wild-type NL4-3 p17. bMutation pairs within an immunologically vulnerable group of co-evolving residues, termed sector 3, that we previously identified qualitatively [12]. cE>90 or E = ∞ were considered high E values and E<15 were considered low E values.
创建时间：
2014-08-07
