<b>Summary of sub-group comparisons within population, disease severity and demographic characteristics.</b>

S, M, L Clinical relevance based on magnitude of point difference (Small:S [5]–[10]; Moderate:M [10]–[20]; Large:L [>20]) (supplementary color Table S11). **Not Statistically Significant (p>0·05). *Not Statistically Significant, multiple testing adjusted (p>0·0033). †Median Age for newly diagnosed = 57 years; Median Age for Recurrent patients = 55 years. ND/Rec Newly Diagnosed/Recurrent – all North American – data was collected between 2001–2009. GP General Population from EORTC reference manual – mostly European– data was collected in the last decade of 20th century.