Genome-wide binding pattern of PU.1 in normal erythroid progenitors and erythroleukemia cells
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https://www.ncbi.nlm.nih.gov/sra/SRP002542
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资源简介：
We find that the myeloid master regulatory transcription factor, PU.1, binds to >16,000 sites in both normal and leukemic erythroid cells. Of these bound sites, ~7,000 lie within 2kb of TSS of a gene, suggesting PU.1 may regulate a large number of genes in erythroid cells. Coupling this data with gene expression analysis, we show PU.1 directly regulates several critical signaling pathways in erythroid cells. Overall design: Assaying PU.1 occupancy in normal and leukemic erythroid cells
创建时间：
2017-09-17
